Figure 2. Fold changes (hypoxic/normoxic) in gene regulation of hepatopancreatic tissue, measured by macroarrays in female specimens of Palaemonetes pugio exposed to cyclic (1.5 mg/l–8 mg/l DO, 4.20–18.88 kPa) hypoxia. Data shown were log₂-transformed and normalized to the array median prior to calculating fold changes, and all changes are significant (P 0.05 [Student's t-test], q < 8 [SAM]). Bar patterns represent gene functional groups. (A) 3-d exposure. (B) 7-d exposure. (C) 14-d exposure. No significant differences were found at 77 d. Gene abbreviations: mMnSOD, mitochondrial Mn-superoxide dismutase; PEP Cbk, phosphoenol pyruvate carboxykinase; rprot S2, mitochondrial ribosomal protein S2; rprot S14, ribosomal protein S14; VLCAD, very-long-chain specific acyl-CoA dehydrogenase.