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Biol Bull 110: 229-242. (June 1956)
© 1956 Marine Biological Laboratory
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A HISTOLOGICAL AND CYTOPHOTOMETRIC STUDY OF THE EFFECTS OF X-RAYS ON THE MOUSE TESTIS

JOHN H. D. BRYAN 1 and JOHN W. GOWEN 1

1 Department of Genetics, Iowa State College, Ames, Iowa

1. Changes in the seminiferous epithelium, induced by 320 r of x-rays, have been analyzed by means of a quantitative histological procedure.

2. With the aid of a cytophotometer, measurements have been made of the DNA-Feulgen content of control and irradiated spermatogonial nuclei.

3. The histological data indicate that irradiation, with 320 r of x-rays, results in a temporary maturation depletion of the seminiferous epithelium. This depletion is brought about through the inhibition of spermatogonial mitosis rather than irradiation-induced spermatogonial necrosis. The frequency of spermatogonia reaches its lowest point by three days after irradiation and regeneration does not begin until after 10 days.

4. The cytophotometric data suggest that irradiation-induced inhibition of DNA synthesis is a contributing factor with respect to the suppression of mitotic activity.






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Copyright © 1956 by the Marine Biological Laboratory.