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Biol Bull 113: 129-134. (August 1957)
© 1957 Marine Biological Laboratory
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THE ANTIMITOTIC AND CARCINOSTATIC ACTION OF OVARIAN EXTRACTS

L. V. HEILBRUNN 1, W. L. WILSON 1, T. R. TOSTESON 1, E. DAVIDSON 1, and R. J. RUTMAN 1

1 Department of Zoology, University of Pennsylvania, and the Marine Biological Laboratory, Woods Hole, Mass.

Extracts of the ovaries of cows, pigs and sheep can suppress mitosis in eggs of the worm Chaetopterus. This they do by keeping the protoplasm fluid and inhibiting the mitotic gelation which is a necessary precursor of the mitotic spindle. The potent substance or substances in extracts of cow ovaries can be precipitated by treating the extracts in the cold with intermediate concentrations of alcohol. Such purified preparations have a definite antimitotic effect and they also have a very definite carcinostatic action.






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Copyright © 1957 by the Marine Biological Laboratory.