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Biol Bull 113: 388-396. (December 1957)
© 1957 Marine Biological Laboratory
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A RATIONAL APPROACH TO THE PROBLEM OF CANCER CHEMOTHERAPY

L. V. HEILBRUNN 1 and W. L. WILSON 1

1 Department of Zoology, University of Pennsylvania, Philadelphia, Pa.; Department of Physiology and Biophysics, University of Vermont, Burlington, Vt.; and the Marine Biological Laboratory, Woods Hole, Mass.

1. Nitrogen mustard, Nitromin, 6-mercaptopurine, and urethane suppress cell division in Chaetopterus eggs.

2. This inhibition of mitosis is due to the fact that these agents keep the protoplasm fluid and prevent the mitotic gelation.

3. In relatively high concentration, both Nitromin and urethane cause a gelation of the protoplasm and in these concentrations, urethane can initiate cell division in a high percentage of the eggs.

4. An interpretation is given of this paradoxical action of reagents in causing either liquefaction or gelation, either suppression or initiation of cell division.

5. The results are believed to provide an explanation of the Haddow paradox.






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Copyright © 1957 by the Marine Biological Laboratory.