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1 Department of Zoology, University of Oklahoma, Norman, Oklahoma
1. A study was made of the effect of the goitrogens thiourea, phenylthiourea and thiouracil on oxygen consumption in planarians.
2. Thiourea and thiouracil were found to have no statistically significant effect.
3. With phenylthiourea there was a marked initial depression, then a gradual return to normal levels followed by a significant rise. In the animals returned to water, oxygen consumption was not reduced to normal levels within four days.
4. It is suggested that the depressant action of the phenylthiourea may be ascribed to its ability to inhibit tyrosinase, while the stimulatory effect may well be due to the toxicity of the goitrogen.
5. A possible effect of thiourea upon sexual activity in planarians was noted.
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