METABOLIC ANTAGONISTS AND PROLONGED SURVIVAL OF SCALE HOMOGRAFTS IN FUNDULUS HETEROCLITUS

¹ Department of Biology, Brown University, Providence, R. I., and Mount Desert Island Biological Laboratory, Salisbury Cove, Maine

1. At 28° C., the melanocytes on scale homografts in Fundulus are destroyed in three days by the immunological response of the host. This reaction is slower to occur at progressively lower temperatures, but is not adversely affected by splenectomy or hypophysectomy of the host, nor by daily injections of trypan blue.

2. Survival of homografts was enhanced by daily intraperitoneal injections of base analogues, potent preparations of adrenal cortical hormones, antibiotics and amino acid analogues.

3. These results are taken to indicate that the inductive and productive phases of antibody formation are particularly vulnerable to agents which interfere with protein and/or nucleic acid synthesis.