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Biol Bull 125: 534-541. (December 1963)
© 1963 Marine Biological Laboratory
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EFFECTS OF METABOLIC INHIBITORS ON PLANARIAN REGENERATION

AGNES A. SMITH 1 and C. S. HAMMEN 1

1 Department of Biology, Adelphi College, Garden City, New York

1. In this investigation, treatment of regenerating worms with 10-8 M p- chloromercuribenzoic acid (PCMB) and 1 mg./ml. avidin resulted in the development of defective eye spots, which were scored according to a numbering system based on Child's classification.

2. The rate of regeneration was not significantly altered by treatment with PCMB and avidin in the concentrations used.

3. A direct relationship was found between duration of exposure to PCMB solutions and frequency of abnormalities.

4. These results indicate that inhibitors of carboxylation enzymes are effective in producing defects in planarian regeneration.






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