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Biol Bull 132: 381-391. (June 1967)
© 1967 Marine Biological Laboratory
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CARDIOREGULATION IN LIMULUS. II. GAMMA AMINOBUTYRIC ACID, ANTAGONISTS AND INHIBITOR NERVES

RALPH A. PAX 1 and RICHARD C. SANBORN 2

1 Department of Biological Sciences, Purdue University, Lafayette, Indiana 47907
2 The Marine Biological Laboratory, Woods Hole, Massachusetts 02543

1. GABA (5 x 10-7 to 5 x 10-5 M) perfused through the isolated Limulus heart mimics stimulation of the cardioinhibitory nerves by decreasing rate and strength of beating of the heart.

2. GABA, unlike activity in the cardioinhibitory nerves, decreases neither the number of units discharging nor the total duration of each burst of electrical activity in the cardiac ganglion.

3. Picrotoxin (1 x 10-3 M) blocks the function of the cardioinhibitory nerves.

4. Picrotoxin (1 x 10-3 M) blocks neither the rate nor the strength-decreasing effects of applied GABA.

5. Since GABA does not mimic the action of the inhibitor nerves and its action is not blocked by an agent blocking the function of the inhibitor nerves, we believe it is probable that GABA is not a transmitter in the Limulus cardioinhibitory pathway.






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Copyright © 1967 by the Marine Biological Laboratory.