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Biol Bull 133: 697-702. (December 1967)
© 1967 Marine Biological Laboratory
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STUDIES OF THE EFFECT OF IRRADIATION OF CELLULAR PARTICULATES. VI. COMPARISON OF UNCOUPLING AT THE THREE PHOSPHORYLATING SITES

HENRY T. YOST 1, MARTHA T. YOST 1, and HOPE H. ROBSON 1

1 Department of Biology, Amherst College, Amherst, Massachusetts 01002

White male rats of Sprague-Dawley strain were exposed to 1000 r total-body ggr-irradiation. Measurements of the uncoupling at each of the three phosphorylating sites in mitochondria isolated from liver and spleen were made. The results indicate that the terminal step (oxidation of reduced cytochrome-c) is the most sensitive of the three and that the great majority, if not all, of the observed uncoupling may result from damage to this step.






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Copyright © 1967 by the Marine Biological Laboratory.