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Biol Bull 144: 180-191. (February 1973)
© 1973 Marine Biological Laboratory
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DEMONSTRATION OF AN ACTION OF ACETYLCHOLINE ON THE CENTRAL NERVOUS SYSTEM OF A CRAB

A. L SORENSON 1

1 Marine Biological Laboratory, Woods Hole, Massachusetts 02543, and Department of Biology, Brooklyn College, Brooklyn, New York 11210

1. The administration of acetylcholine to the thoracic ganglion of Carcinus by means of the sternal artery resulted in leg movements. Low concentrations of acetylcholine were effective and the action of acetycholine was potentiated by eserine and attenuated by atropine.

2. Injection of acetylcholine into the thoracic ganglion by means of electroosmotic injection caused electrical activity in the ganglion and desensitization was found to accompany this activity.

3. The present results and those of other investigators indicate that the classical pharmacological criteria for identification of ACh as a chemical transmitter appear to be fulfilled.






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Copyright © 1973 by the Marine Biological Laboratory.