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Biol Bull 161: 98-103. (August 1981)
© 1981 Marine Biological Laboratory
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A LYTIC MOLECULE ACTIVE AGAINST A CILIATE DURING A TRANSMISSIBLE DISEASE OF SIPUNCULUS NUDUS

FREDERIK B. BANG 1 and HYUN S. SHIN 2

1 Station Biologique, Roscoff, France
2 The Johns Hopkins University, Baltimore, Maryland

A pox-like disease of Sipunculus nudus was transmitted experimentally and serially by scarifying the skin of normal specimens of Sipunculus and exposing them in an open dish of running seawater to spontaneously infected animals. Animals allowed to repenetrate the sand during the incubation period did not develop signs of infection.

A lysin which destroys ciliates (Anophrys), obtained from crab blood, appeared about 4-6 days after infection and persisted until death of the animal at 16-20 days from ulceration and secondary infection. The lysin was stabilized by mixing the cell-free fluid with 0.01 M EDTA, and full activity was recoverable in one peak on Sephadex-200 gel. The molecular weight was estimated as about 250,000 daltons.

Submitted on March 16, 1981
Accepted on April 27, 1981






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Copyright © 1981 by the Marine Biological Laboratory.