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Biol Bull 169: 256-266. (August 1985)
© 1985 Marine Biological Laboratory
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A NOVEL FMRFamide-RELATED PEPTIDE IN HELIX: pQDPFLRFamide

D. A. PRICE 1, G. A. COTTRELL 2, K. E. DOBLE 1, M. J. GREENBERG 1, W. JORENBY 3, H. K. LEHMAN 1, and J. P. RIEHM 3

1 C. V. Whitney Laboratory, University of Florida, Rt. 1, Box 121, St. Augustine, Florida 32086
2 Department of Physiology and Pharmacology, University of St. Andrews, Fife, KY16 9TS, United Kingdom
3 Department of Biology, University of West Florida, Pensacola, Florida 32514

A novel FMRFamide-like peptide, purified from the ganglia of Helix aspersa, has the amino acid sequence: pyroglutamyl-aspartyl-prolyl-phenylalanyl-leucyl-arginyl-phenylalanine amide (pQDPFLRFamide). Synthetic pQDPFLRFamide was prepared; it is chromatographically and biologically indistinguishable from the natural peptide, confirming the sequence. pQDPFLRFamide is about a hundred times more potent than FMRFamide on the isolated Helix heart, but slightly less potent than FMRFamide on the Busycon radula protractor muscle. Since pQDPFLRFamide occurs in Helix blood at levels sufficient to excite the isolated Helix heart, it may act as a cardioregulatory hormone.

Submitted on January 21, 1985
Accepted on May 16, 1985




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K. G. Krajniak
Annelid Endocrine Disruptors and a Survey of Invertebrate FMRFamide-Related Peptides
Integr. Comp. Biol., January 1, 2005; 45(1): 88 - 96.
[Abstract] [Full Text] [PDF]


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