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Biol Bull 172: 132-136. (February 1987)
© 1987 Marine Biological Laboratory
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PHARMACOLOGICAL ACTIONS OF THE MARINE TOXINS CIGUATOXIN AND MAITOTOXIN ISOLATED FROM POISONOUS FISH

YASUSHI OHIZUMI 1

1 Mitsubishi-Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194, Japan

Ciguatoxin and maitotoxin isolated from poisonous fish and toxic dinoflagellates exhibited a powerful excitatory effect on smooth and cardiac muscle. The ciguatoxin-induced excitatory action is due to an increase in Na+ permeability of tetrodotoxin sensitive Na channels, while the maitotoxin-induced excitatory effect is caused by an increased Ca2+ permeability of the cell membrane.






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Copyright © 1987 by the Marine Biological Laboratory.