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The Biological Bulletin, Vol 179, Issue 1 77-86, Copyright © 1990 by Marine Biological Laboratory

INVITED REVIEW

Hsr-omega, A Novel Gene Encoded by a Drosophila Heat Shock Puff

M. L. Pardue, W. G. Bendena, M. E. Fini, J. C. Garbe, N. C. Hogan and K. L. Traverse
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Although originally identified because of its abundant transcription in heat shock, the hsr-omega gene is active, at generally lower levels, in non-stressed cells. The locus produces an unusual set of three transcripts. Evidence from a variety of experiments suggests that one of these transcripts acts in the nucleus, possibly to regulate the activity of a nuclear protein. Another of the transcripts appears to act in the cytoplasm, possibly monitoring or regulating some aspect of translation. The two transcripts together could have a role in coordinating nuclear and cytoplasmic activity. A number of processes occur in eukaryotic cells in which nuclear and cytoplasmic activities need to be coordinated; we suggest that hsr-omega plays a role in such coordination.


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 Proc. Natl. Acad. Sci. USAHome page
S. W. McKechnie, M. M. Halford, G. McColl, and A. A. Hoffmann
Both allelic variation and expression of nuclear and cytoplasmic transcripts of Hsr-omega are closely associated with thermal phenotype in Drosophila
PNAS, March 3, 1998; 95(5): 2423 - 2428.
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