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Biol Bull 78: 92-102. (February 1940)
© 1940 Marine Biological Laboratory
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ACETYLCHOLINE AND NERVOUS INHIBITION IN THE HEART OF VENUS MERCENARIA

C. LADD PROSSER 1

1 From the Marine Biological Laboratory, Woods Hole, Mass., and the Biological Laboratories, Clark University, Worcester, Mass.

The heart of Venus is sensitive to acetylcholine in dilutions of 10–12 during the spring and 10–9 during the fall. It is useful as a test material for acetylcholine assay.

Acetylcholine appears to leave the contracting mechanism intact and to act on the pacemaker and conducting mechanisms of this myogenic heart.

Stimulation of the visceral ganglion causes inhibition in diastole resembling the effect of acetylcholine.

Atropine is very toxic to the heart. In non-toxic concentrations it antagonizes neither the effect of acetylcholine nor of nerve inhibition.

Fluid from a heart inhibited by visceral ganglion stimulation often depresses the beat of an eserinized test heart.

Eserine prolongs the inhibition due to acetylcholine and that due to nerve stimulation. It appears likely that acetylcholine is liberated as the normal cardiac inhibitory agent in Venus.






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