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Biol Bull 78: 189-201. (April 1940)
© 1940 Marine Biological Laboratory
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THE ORIGIN OF THE DIABETOGENIC HORMONE IN THE DOGFISH

A. A. ABRAMOWITZ 1, F. L. HISAW 1, E. BOETTIGER 1, and D. N. PAPANDREA 1

1 From the Woods Hole Oceanographic Institution, and the Biological Laboratories, Harvard University

The resting blood sugar level and the severity of pancreatic diabetes are not influenced by fluctuations in intermedin secretion in the dogfish. Complete hypophysectomy is followed by the appearance of hypoglycemia on the fourth day following the operation, a response which is also produced by the removal of the anterior lobe alone. Removal of the neuro-intermediate lobe does not affect the resting blood sugar level. Complete hypophysectomy ameliorates the severity of pancreatic diabetes, as does the removal of the anterior lobe alone. The removal of the neurointermediate lobe alone does not influence pancreatic diabetes. These results show that intermedin and the diabetogenic hormones of the pituitary of the dogfish are not identical.






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