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1 From the Laboratory of F. Holtz, Berlin-Frohnau and the Department of Biology, The Catholic University of America, Washington, D. C.
1. Monthly analyses on different blood constituents of Helix pomatia showed that their concentration may vary considerably.
2. The mean values, gained from a large number of analyses, indicate, however, that there is no significant difference between the blood composition during the time of hibernation and that of active life. This is due to the fact that most, if not all, of the variability is due to climatic variations which balance out if observations are made over a long period
3. In snails forming the epiphragma the blood proteins and P were found in a certain concentration, but not the other inorganic substances.
4. The blood constituents become diluted by intake of water in snails shedding the epiphragma.
5. Short periods of dryness do not materially change the blood composition.
6. An alimentary hyperglycemia can be produced easily by feeding sugar to the snails.
7. In the early stages of shell regeneration the blood calcium is higher than normal.
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