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Biol Bull 79: 432-438. (December 1940)
© 1940 Marine Biological Laboratory
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THE DISTRIBUTION OF INTERMEDIN: FIRST APPEARANCE OF THE HORMONE IN THE EARLY ONTOGENY OF RANA PIPIENS

L. H. KLEINHOLZ 1

1 From the Biological Laboratories, Harvard University, Cambridge, Massachusetts

1. Quantitative assays for the first appearance of intermedin in larvae of R. pipiens were made, usingthe hypophysectomized lizard, Anolis carolinensis, as test animal.

2. Intermedin is detectable with the establishment of the hypophyseal primordium as an invagination from the buccal ectoderm. The gland from larvae 4-7 mm. in length contains approximately 0.3 Anolis unit of intermedin.

3. Intermedin appears before cytological differentiation of the pituitary gland occurs.






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Copyright © 1940 by the Marine Biological Laboratory.