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Biol Bull 89: 122-130. (August 1945)
© 1945 Marine Biological Laboratory
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A COMPARISON OF THE EFFECTS OF CYANIDE AND AZIDE ON THE DEVELOPMENT OF FROGS' EGGS

S. SPIEGELMAN 1 and FLORENCE MOOG 1

1 Department of Zoology, Washington University, Saint Louis 5, Missouri

Previous observations that amphibian eggs can develop up to the beginning of gastrulation in cyanide solutions have been confirmed on eggs of Rana pipiens. The effect of cyanide is independent of pH, and eggs can develop into tadpoles in 2.5 x 10-4 molar NaOH or KOH solutions at pH 9.8.

Azide has been found to arrest development immediately in all stages from fertilization to tail-bud formation. The effect is the same from pH 6.6 to pH 8.3.

These differences are discussed in the light of recent studies on the effects of azide and cyanide on respiratory, assimilatory. and phosphorylative processes.






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