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Biol Bull 94: 79-85. (April 1948)
© 1948 Marine Biological Laboratory
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RETARDATION OF CELL DIVISION BY VITAMIN C IN PHYSIOLOGICAL CONCENTRATIONS

HERBERT SHAPIRO 1

1 From the Laboratory of Physical Biology, National Institute of Health, Bethesda, Maryland, and the Marine Biological Laboratory, Woods Hole, Mass.

a. Eggs of the sea urchin, Arbacia punctulata, were exposed to concentrations of vitamin C in sea water, varying from 2.62 x 10-6 molar to 1.57 x 10-3 molar. The rate of cell division was determined by measuring the time required for 50 per cent of the cells to go through first cleavage.

b. Beginning with approximately 10-5 molar solutions, a definite retardation of cell division was observed. At high concentrations, complete inhibition of division occurred. At an intermediate concentration, the total percentage of cells dividing may be reduced from 100 per cent to some smaller figure.

c. Although cleavage was retarded in the presence of vitamin C, it appeared to be normal in other respects, with the exception of irregular cleavages at the high concentrations.

d. The slowing down of the rate of cell division appears to be roughly a linear function of the concentration, beyond a minimal concentration.






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