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Biol Bull 95: 346-353. (December 1948)
© 1948 Marine Biological Laboratory
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THE ACTION OF CHOLINE AND RELATED COMPOUNDS ON THE HEART. OF VENUS MERCENARIA

JOHN H. WELSH 1 and RAE TAUB 1

1 Biological Laboratories, Harvard University

1. A method of preparing and employing the isolated heart of the quahog, Venus mercenaria, for the bio-assay of acetylcholine (Ach) is described.

2. The activities of choline and certain choline esters; of betaine and its ethyl ester; and of triethylcholine and triethyl-acetylcholine on the isolated Venus heart are compared. In further understanding the fundamental mode of action of Ach, the most significant observation was that the substitution of ethyl groups for methyl on the nitrogen of choline and Ach resulted in a complete loss of activity determined by observation on the amplitude of heart beat.




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M. J. Greenberg and D. A. Windsor
Action of Acetylcholine on Bivalve Hearts
Science, August 17, 1962; 137(3529): 534 - 535.
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J. H. Welsh and R. Taub
Molecular Configuration and Biological Activity of Substances Resembling Acetylcholine
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Copyright © 1948 by the Marine Biological Laboratory.