Biol. Bull. Sign up for etocs!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Biol Bull 97: 138-144. (October 1949)
© 1949 Marine Biological Laboratory
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ELLENBOGEN, S.
Right arrow Articles by OBRESHKOVE, V.
Right arrow Search for Related Content
PubMed
Right arrow Articles by ELLENBOGEN, S.
Right arrow Articles by OBRESHKOVE, V.

ACTION OF ACETYLCHOLINE, CARBAMINOYL-CHOLINE (DORYL) AND ACETYL-B-METHYL-CHOLINE (MECHOLYL) ON THE HEART OF A CLADOCERAN

SAUL ELLENBOGEN 1 and VASIL OBRESHKOVE 1

1 From the Department of Biology, Bard College

1. Acetylcholine, carbaminoyl-choline and acetyl-B-methyl-choline produce in Simocephalus vetulus cardiac excitation. The heart acceleration in each case was followed by inhibition.

2. This action of the drugs is antagonized by atropine and augmented by prostigmine and physostigmine.

3. Acetylcholine exhibits a graded action for a wide range of concentrations (1 x 10-2 to 1 x 10-9) as revealed by the time required for the production of a maximum cardiac excitation.

4. In contrast with carbaminoyl-choline, a marked antagonism was found to exist between acetyl-B-methyl-choline and atropine. When atropine is followed by carbaminoyl-choline, the Doryl effect appears in comparatively short periods of time.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1949 by the Marine Biological Laboratory.