Data Supplements

Files in this Data Supplement:

• Supplemental Table 1 - Candidate stress-response genes in the Nematostella vectensis genome were identified by protein domain searches as depicted in Figure 2. The search results are organized by major type of stressor (chemical, pathogen, or wound) and then by protein domain (PFAM Accession). Each Nematostella predicted gene (StellaBase ID) that scores a significant match to a given domain was first identified using a Hidden Markov Model search of StellaBase. The best hit at StellaBase was then cross-referenced with its GenBank entry (Nv GenBank ID). The best human match to each Nematostella gene was then identified using a BLASTp search of GenBank. For the top human match, the Gene ID, definition line, and significance score are provided.
• Supplemental Table 2 - The number of genes matching stress-related protein domains in seven different model systems. The domains are organized by major type of stressor (chemical, pathogen, and wound). Each domain is identified by its Domain Name, Description, PFAM identification number (Acc) and version (Ver). Model systems included in the search were Nematostella vectensis (Nv), Escherichia coli (Ec), Arabidopsis thaliana (At), Saccharomyces cerevisiae (Sc), Caenorhabditis elegans (Ce), Drosophila melanogaster (Dm), and Homo sapiens (Hs).